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Bovine corpus luteum regression and estrous response following treatment with alfaprostol.

Abstract
Two trials evaluated bovine corpus luteum (CL) regression and estrous response following treatment with alfaprostol (AP), a prostaglandin F2 alpha analogue. Expression of at least one estrous cycle (16 to 26 d) and a palpable mid-cycle CL were required prior to random assignment of females to receive 0, .38, .75, 1.50 or 2.25 mg AP/100 kg body weight. Alfaprostol was evaluated in Brahman cows and heifers that were treated on d 11 to 13 (trial 1) and in Simmental X Brahman-Hereford (crossbred) heifers that were treated on d 8 to 10 or d 11 to 13 of the estrous cycle (trial 2). In trial 1, Brahman heifers appeared to require a higher AP dose (greater than .38 mg/100 kg body weight) to elicit luteolysis and expression of estrus than Brahman cows. Alfaprostol treatment (greater than or equal to .75 mg/100 kg body weight) induced (P less than .0001) luteolysis followed by estrus in Brahman cows and heifers. In trial 2, crossbred heifers that received AP on d 8 to 10 appeared to require a higher dose of AP (greater than .38 mg/100 kg body weight) to elicit luteolysis and estrus than heifers that received AP on d 11 to 13 of the estrous cycle. Alfaprostol treatment greater than or equal to .75 mg/100 kg body weight on d 8 to 10 and d 11 to 13 of the estrous cycle induced (P less than .0001) luteolysis followed by estrus in crossbred heifers.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsT R Hansen, R D Randel, L A Peterson
JournalJournal of animal science (J Anim Sci) Vol. 64 Issue 5 Pg. 1280-4 (May 1987) ISSN: 0021-8812 [Print] United States
PMID3583939 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Prostaglandins F
  • alfaprostol
Topics
  • Animals
  • Cattle (physiology)
  • Estrus (drug effects)
  • Female
  • Luteolysis (drug effects)
  • Prostaglandins F (pharmacology)

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