Abstract |
The purpose of this study was to determine the effect of rifampin and its cyclopentyl analogue, MDL 473, on delayed type hypersensitivity (DTH) using a murine model. Neither compound has any significant effect on DTH (as measured by ear swelling) to oxazolone when administered i.p. to BALB/c mice at doses of 1, 10, 50 or 100 mg/kg beginning 3 days before oxazolone sensitization and continuing until hapten challenge 5 days later. In contrast, sex and age matched controls receiving 200 mg hydrocortisone/kg i.p. beginning on the day of oxazolone sensitization and continuing to hapten challenge demonstrate a significant (P less than 0.001) abrogation of DTH.
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Authors | M T Kenny |
Journal | International journal of immunopharmacology
(Int J Immunopharmacol)
Vol. 9
Issue 2
Pg. 257-60
( 1987)
ISSN: 0192-0561 [Print] England |
PMID | 3583511
(Publication Type: Journal Article)
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Chemical References |
- Oxazolone
- Rifampin
- Hydrocortisone
- rifapentine
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Topics |
- Animals
- Female
- Hydrocortisone
(pharmacology)
- Hypersensitivity, Delayed
(drug therapy, etiology)
- Mice
- Mice, Inbred BALB C
- Oxazolone
(immunology)
- Rifampin
(analogs & derivatives, pharmacology)
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