Efficacy, tolerance and predictors of response to the treatment with hyperbaric oxygen therapy for patients with hemorrhagic radiation cystitis.

Abstract

OBJECTIVES:

The aim was to study the efficacy and tolerance in patients with haemorrhagic radiation-induced cystitis (HRC) treated with hyperbaric oxygen therapy (HOT) and analyze which factors were related to the response to the treatment.

MATERIAL AND METHODS:

We performed a retrospective cohort study of patients treated with HOT for HRC symptoms in a provincial referral centre from 2010 to 2020. We evaluated clinical response to treatment, number of hospitalizations due to HRC and subjective response using the PGI-I questionnaire.

RESULTS:

We treated 52 patients, with a median of 30 sessions, during 6 months and 40 months (6-68 months) of follow-up. 69.2%of patients responded completely and 21,2% partially. The 53.2% of patients improved before the first 10 sessions. Reduction of hospitalizations/per year due to haematuria from 2.8 to 1.1 (p=0,001). The 73,5% of patients stated that they were "very much better" or "much better" after treatment. During the follow-up, 15.4% of patients had recurrence of HRC. 9.6% of the patients required salvage cystectomy. The patients with a highest RTOG-EORTC scale had more risk to still with symptoms (OR 3.01 (IC95 1.48 - 6.16). All patients were able to complete the proposed treatment plan with good tolerance to HOT.

CONCLUSIONS:

These results show the clinical benefit of HOT in the treatment of HRC, with a reduction of the number of hospitalizations and a subjective improvement.

• Authors: Pau Sarrió-Sanz, Laura Sanchez-Caballero, Laura Martinez-Cayuelas, Carlos Francisco Gori, Juan José Pacheco-Bru, Baraa Nakdali-Kassab, Miguel Gómez-Garberí, Pablo Caballero-Perez, Luis Gomez-Perez, Manuel Angel Ortiz-Gorraiz
• Journal: Archivos espanoles de urologia (Arch Esp Urol) Vol. 75 Issue 4 Pg. 354-360 (May 28 2022) ISSN: 0004-0614 [Print] Spain
• PMID: 35818916 (Publication Type: Journal Article)

Topics

• Cystitis (etiology, therapy)
• Hemorrhage (therapy)
• Humans
• Hyperbaric Oxygenation (methods)
• Radiation Injuries (therapy)
• Retrospective Studies
• Treatment Outcome