Abstract |
Antiarrhythmic effects of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid ( BK 129) was studied in pentobarbital anesthetized dogs. The dose of 1 mg kg-1 i.v. suppressed ouabain-induced ventricular tachycardia for approx. 15 min. The minimal effective dosis was 0.72 +/- 0.09 mg kg-1 in comparison with 4.56 +/- 1.90 mg kg-1 of trimecaine and 6.80 +/- 0.86 mg kg-1 of quinidine. The doses of 1 and 2 mg kg-1 decreased ectopic activity 24-48 h after coronary artery ligation without complete suppression of extrasystoles. Epinephrine-induced arrhythmias were not prevented with the dose of 1 mg kg-1. The results demonstrate effectiveness of BK 129 in suppression of some types of arrhythmias.
|
Authors | P Gibala, R Sotníková, V Knezl, J Drímal |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 37
Issue 2
Pg. 149-52
(Feb 1987)
ISSN: 0004-4172 [Print] Germany |
PMID | 3580018
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Arrhythmia Agents
- Azepines
- BK 129
|
Topics |
- Animals
- Anti-Arrhythmia Agents
(therapeutic use)
- Arrhythmias, Cardiac
(drug therapy)
- Azepines
(therapeutic use)
- Disease Models, Animal
- Dogs
- Electrocardiography
- Female
- Heart Rate
(drug effects)
- Heart Ventricles
(drug effects)
- Male
- Structure-Activity Relationship
- Tachycardia
(drug therapy)
|