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Antiarrhythmic activity of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid.

Abstract
Antiarrhythmic effects of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid (BK 129) was studied in pentobarbital anesthetized dogs. The dose of 1 mg kg-1 i.v. suppressed ouabain-induced ventricular tachycardia for approx. 15 min. The minimal effective dosis was 0.72 +/- 0.09 mg kg-1 in comparison with 4.56 +/- 1.90 mg kg-1 of trimecaine and 6.80 +/- 0.86 mg kg-1 of quinidine. The doses of 1 and 2 mg kg-1 decreased ectopic activity 24-48 h after coronary artery ligation without complete suppression of extrasystoles. Epinephrine-induced arrhythmias were not prevented with the dose of 1 mg kg-1. The results demonstrate effectiveness of BK 129 in suppression of some types of arrhythmias.
AuthorsP Gibala, R Sotníková, V Knezl, J Drímal
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 37 Issue 2 Pg. 149-52 (Feb 1987) ISSN: 0004-4172 [Print] Germany
PMID3580018 (Publication Type: Journal Article)
Chemical References
  • Anti-Arrhythmia Agents
  • Azepines
  • BK 129
Topics
  • Animals
  • Anti-Arrhythmia Agents (therapeutic use)
  • Arrhythmias, Cardiac (drug therapy)
  • Azepines (therapeutic use)
  • Disease Models, Animal
  • Dogs
  • Electrocardiography
  • Female
  • Heart Rate (drug effects)
  • Heart Ventricles (drug effects)
  • Male
  • Structure-Activity Relationship
  • Tachycardia (drug therapy)

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