Failure of tetracycline therapy in early Lyme disease.

We describe the clinical courses of 5 patients with Lyme disease who developed significant late complications, despite receiving tetracycline early in the course of their illness. All 5 patients had been treated for erythema chronicum migrans with a course of tetracycline that met or exceeded current recommendations. The late manifestations of Lyme disease included arthritis, cranial nerve palsy, peripheral neuropathy, chronic fatigue, and changes in mental function. Our findings suggest that the use of tetracycline at a dosage of 250 mg, 4 times a day for 10 days, as a treatment for early Lyme disease should be reconsidered. To determine optimal therapy for early Lyme disease, a study that compares an increased dosage of tetracycline with alternative treatments is indicated.
AuthorsR J Dattwyler, J J Halperin
JournalArthritis and rheumatism (Arthritis Rheum) Vol. 30 Issue 4 Pg. 448-50 (Apr 1987) ISSN: 0004-3591 [Print] UNITED STATES
PMID3580012 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Tetracycline
  • Adolescent
  • Adult
  • Arthritis, Infectious (etiology)
  • Female
  • Humans
  • Lyme Disease (complications, drug therapy)
  • Male
  • Middle Aged
  • Nervous System Diseases (etiology)
  • Recurrence
  • Tetracycline (therapeutic use)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: