HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Putative role of antireticulin antibody in antiacetylcholine-receptor-antibody-negative myasthenia gravis.

Abstract
It has recently been demonstrated that pathogenic immunoglobulins circulate in the blood of patients with acetylcholine-receptor-antibody (A-AChR)-negative myasthenia gravis (MG). Evidence has been presented that in this form of MG the neuromuscular transmission is impaired by antibodies that bind to endplate determinants other than the AChR. We describe three patients with clinical manifestations of A-AChR-negative MG in whom antibody directed to reticulin (A-Ret) was detected. Antibody directed to reticulin is usually associated with celiac disease; however, none of the patients had symptoms or signs of celiac disease. To our knowledge, the association of A-Ret with A-AChR-negative MG has not been reported before. We postulate that A-Ret might help to differentiate between A-AChR-negative MG and congenital myasthenia. Further studies are needed to determine whether A-Ret plays a pathogenic role in A-AChR-negative MG or should instead be considered as an epiphenomenon.
AuthorsT U Hoogenraad, F H Gmelig Meyling
JournalArchives of neurology (Arch Neurol) Vol. 44 Issue 5 Pg. 536-8 (May 1987) ISSN: 0003-9942 [Print] United States
PMID3579665 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Autoantibodies
  • Reticulin
  • Edrophonium
  • Pyridostigmine Bromide
  • Prednisone
Topics
  • Adult
  • Autoantibodies (immunology)
  • Edrophonium (therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myasthenia Gravis (drug therapy, immunology)
  • Prednisone (therapeutic use)
  • Pyridostigmine Bromide (therapeutic use)
  • Reticulin (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: