Analysis of dose and duration dependent effects of Allium sativum Linn and other hypocholesterolemic agents exhibited on dyslipidemia in patients with essential hypertension.

Abstract

Globally, cardiovascular diseases (CVD) are one of the most significant cause of organ failure, mortality and substantial escalation of health care cost. Dyslipidemia and hypertension poses significant risks in cardiovascular diseases and morbidity and mortality can be minimized by altering risks factors. Dyslipidemia is one of the major leading cause of rise of global incidences and socioeconomic burden which necessitates to explore the pharmacological options of significant antilipemic activity with minimal untoward effects at affordable price. Allium Sativum (Garlic) proved medicinally effective in different clinical trials, but further investigations are required to investigate its effects on diabetes, hypertension and dyslipidemia based on variable doses and duration. In this study dose and duration dependent effects of Garlic were evaluated on hypertensive patients with dyslipidemia. Study was randomized, single blind and placebo controlled. Effects of tablets of garlic (KWAI) 300 mg in doses of daily 0.3g, 0.6g, 0.9g, 1.2g and 1.5g for 24 weeks were compared in humans. Each tablet contains 1.3 percent of alliin and 0.6 % of allicin. Results showed remarkable improvements in different serum lipid levels (Cholesterol, Triglycerides, Low density lipoproteins and High density lipoproteins) based on different doses and duration as compared to placebo and standard Lipid-lowering agent simvastatin.

• Authors: Rizwan Ashraf, Muhammad Sarwar, Noor Kamil, Shahid Wahid, Absar Qureshi
• Journal: Pakistan journal of pharmaceutical sciences (Pak J Pharm Sci) Vol. 35 Issue 3 Pg. 777-784 (May 2022) ISSN: 1011-601X [Print] Pakistan
• PMID: 35791476 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Biological Products
• Hypolipidemic Agents
• Lipoproteins, HDL

Topics

• Antioxidants
• Biological Products
• Cardiovascular Diseases
• Dyslipidemias (drug therapy)
• Essential Hypertension
• Garlic
• Hematologic Diseases
• Humans
• Hypertension (drug therapy)
• Hypolipidemic Agents
• Lipoproteins, HDL
• Single-Blind Method