Abstract | BACKGROUND: METHODS: The US Lymphoma CAR T Consortium includes seventeen US academic centers that contribute data independently of manufacturers. We analyzed the modified intent-to-treat population of 275 patients receiving axi-cel in two different ways: 1) Two group analysis comparing no CRS with any grade CRS; 2) Three group analysis comparing grade 0 CRS with grade 1 to 2 CRS, and grade 3-5 CRS. RESULTS: In this large multi-center observational cohort of 275 patients receiving axi-cel, 9% (n = 24) did not develop CRS, 84% (n = 232) developed grade 1-2 CRS, and 7% (n = 19) developed grade 3 to 5 CRS. Patients without CRS, compared with those having any grade CRS, had similar overall response rates (ORR), lower complete response (CR) rates and inferior progression free survival (PFS) with no statistically significant difference in overall survival (OS). Patients experiencing grade 1 to 2 CRS had superior CR rate and PFS, as compared to those without CRS or with grade 3 to 5 CRS. Grade 3 to 5 CRS was associated with a worse OS. CONCLUSION: Overall, durable responses were seen in patients that did not develop CRS, however grade 1 to 2 CRS was associated with better outcomes while those with grade 3 to 5 experienced the worse outcomes.
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Authors | Miriam T Jacobs, Michael D Jain, Feng Gao, Loretta J Nastoupil, Jay Y Spiegel, Yi Lin, Saurabh Dahiya, Matthew Lunning, Lazaros Lekakis, Patrick M Reagan, Olalekan O Oluwole, Joseph McGuirk, Abhinav Deol, Alison Sehgal, Andre Goy, Brian T Hill, Charalambos Andreadis, Javier Munoz, Julio C Chavez, N Nora Bennani, Aaron P Rapoport, Julie M Vose, David B Miklos, Sattva S Neelapu, Armin Ghobadi, Frederick L Locke |
Journal | Clinical lymphoma, myeloma & leukemia
(Clin Lymphoma Myeloma Leuk)
Vol. 22
Issue 10
Pg. 753-759
(10 2022)
ISSN: 2152-2669 [Electronic] United States |
PMID | 35780055
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
- Antigens, CD19
- Biological Products
- Receptors, Chimeric Antigen
- axicabtagene ciloleucel
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Topics |
- Antigens, CD19
(therapeutic use)
- Biological Products
- Cytokine Release Syndrome
- Humans
- Immunotherapy, Adoptive
(adverse effects, methods)
- Lymphoma, Follicular
(etiology)
- Lymphoma, Large B-Cell, Diffuse
- Receptors, Chimeric Antigen
(therapeutic use)
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