A rare case of fibrohistiocytic hepatic inflammatory pseudotumor with cholecystocholangitis showing positive IgG4 staining.

Abstract

Inflammatory pseudotumor (IPT) is a rare benign mass characterized by infiltration of inflammatory cells and proliferation of fibrous tissues. Consistent with increasing knowledge about IgG4-related disease (RD), it has been implicated in the etiology of hepatic IPT, which is pathologically classified into two categories with respect to the proportion of IgG4-positive plasma cells: fibrohistiocytic- and lymphoplasmacytic-type. A 66-year-old man was admitted for treatment of cholecystocholangitis. Incidentally, abdominal computed tomography (CT) revealed an ambiguous low-density mass within segment 4 (S4) of the liver. Magnetic resonance imaging (MRI) showed the typical images of hepatic IPT within S4. Together with CT and MRI imaging, we suspected hepatic IPT, and had the opportunity to biopsy the S4 lesion during surgery for cholecystitis. Histopathological examination of liver tissue showed diffuse fibrous tissues, dense lymphoplasmacytic infiltration, and obliterative phlebitis with no evidence of malignancy. Despite infiltration of IgG4-positive plasma cells, these histological findings corresponded with fibrohistiocytic-type hepatic IPT. Similarly, in the resected gallbladder, relatively abundant IgG4-positive cells were observed, but not entirely consistent with IgG4-RD criteria. Although IgG4 immunostaining can be useful for the classification of hepatic IPT, the present histological tissues were borderline condition defined by IgG4-RD criteria. This rare case of hepatic IPT suggests a future focus on the borderline histological features of IgG4-RD.

• Authors: Ai Miyagi, Daisaku Fujimoto, Akina Yoshikawa, Seiko Okushi, Junko Miyagi, Ryosuke Matsumoto, Shinya Ogata, Yoshiaki Bando, Hirohisa Ogawa, Toshihito Tanahashi
• Journal: Clinical journal of gastroenterology (Clin J Gastroenterol) Vol. 15 Issue 5 Pg. 975-980 (Oct 2022) ISSN: 1865-7265 [Electronic] Japan
• PMID: 35773570 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2022. Japanese Society of Gastroenterology.

Chemical References

• Immunoglobulin G

Topics

• Aged
• Granuloma, Plasma Cell (diagnosis, diagnostic imaging)
• Humans
• Immunoglobulin G
• Immunoglobulin G4-Related Disease
• Immunohistochemistry
• Male
• Staining and Labeling