Abstract | Purpose: To compare peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) thickness measurements obtained with spectral domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT) using an OCT-angiography scanning protocol, and their ability to distinguish among patients with glaucoma, glaucoma suspects (GS), and healthy controls (HC). Methods: Cross-sectional study of 196 eyes (81 glaucoma, 48 GS, and 67 HC) of 119 participants. Participants underwent peripapillary and macular OCT with SD-OCT and SS-OCT. Parameters of interest were average and sector-wise pRNFL and mGCIPL thickness. Inter-device agreement was investigated with Bland-Altman statistics. Conversion formulas were developed with linear regression. Diagnostic performances were evaluated with area under the receiver operating characteristic curves. Results: Both SD-OCT and SS-OCT detected a significant pRNFL and mGCIPL thinning in glaucoma patients compared to HC and GS for almost all study sectors. A strong linear relationship between the two devices was present for all quadrants/sectors (R2 ≥ 0.81, P < 0.001), except for the nasal (R2 = 0.49, P < 0.001) and temporal (R2 = 0.62, P < 0.001) pRNFL quadrants. SD-OCT and SS-OCT measurements had a proportional bias, which could be removed with conversion formulas. Overall, the two devices showed similar diagnostic abilities. Conclusions: Thickness values obtained with SD-OCT and SS-OCT are not directly interchangeable but potentially interconvertible. Both devices have a similar ability to discriminate glaucoma patients from GS and healthy subjects. Translational Relevance: OCT-Angiography scans can be reliably used to obtain structural metrics in glaucoma patients.
|
Authors | Alessandro Rabiolo, Federico Fantaguzzi, Giovanni Montesano, Maria Brambati, Riccardo Sacconi, Francesco Gelormini, Giacinto Triolo, Paolo Bettin, Giuseppe Querques, Francesco Bandello |
Journal | Translational vision science & technology
(Transl Vis Sci Technol)
Vol. 11
Issue 6
Pg. 27
(06 01 2022)
ISSN: 2164-2591 [Electronic] United States |
PMID | 35767273
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Cross-Sectional Studies
- Glaucoma
(diagnostic imaging)
- Humans
- Nerve Fibers
- Optic Disk
- Retinal Ganglion Cells
- Tomography, Optical Coherence
(methods)
|