Abstract | PURPOSE: METHODS: Observational multicentre study including all patients from 18 centres with an IVI initially planned during the lockdown. Visual acuity (VA, ETDRS) was recorded at 1 and 4 months after lockdown. French COVID 19-related guidelines recommended maintaining IVI practice. We defined three groups of patients: A, adherent to guidelines; NA+, non-adherent with delayed IVIs; and NA-, non-adherent without IVIs performed during the lockdown. Risk factors for non-adherence and visual loss were studied. RESULTS: A total of 3020 eyes of 3020 patients, aged 77.8 ± 11.6 years, 59.8% women, were included. 59.3% were non-adherent(46.7% NA+, 12.6% NA-). A smaller decrease in VA at 4 months was observed in the A group than the NA+ and NA- group (-0.2 ± 6.7, -0.3 ± 6.9 and -1.5 ± 6.9, respectively [p < 0.001]). Factors associated with non-adherence were in multivariable analysis, older age, hospital practice, low-density population areas, high viral incidence areas, longer intervals between injection and treat and extent protocol. Factors associated with visual loss at 4 months in multivariable analysis were, being in the NA- group, older age, T&E and fixed regimens. CONCLUSION: Strict adherence to guidelines was associated with better visual outcome, although most of our patients did not attend as planned. Identification of patients at risk could help in the future in case of a new pandemic lockdown.
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Authors | Victoire Hurand, Jean-Baptiste Ducloyer, Florian Baudin, Serge Aho, Michel Weber, Laurent Kodjikian, François Devin, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Pascale Massin, CFSR Research Net |
Journal | Acta ophthalmologica
(Acta Ophthalmol)
Vol. 101
Issue 1
Pg. 91-99
(Feb 2023)
ISSN: 1755-3768 [Electronic] England |
PMID | 35765939
(Publication Type: Multicenter Study, Observational Study, Journal Article)
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Copyright | © 2022 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. |
Chemical References |
- Ranibizumab
- Angiogenesis Inhibitors
- Vascular Endothelial Growth Factor A
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Humans
- Female
- Male
- Ranibizumab
- Angiogenesis Inhibitors
- Vascular Endothelial Growth Factor A
- Intravitreal Injections
- Receptors, Vascular Endothelial Growth Factor
- COVID-19
(epidemiology)
- Communicable Disease Control
- Retinal Diseases
(drug therapy, epidemiology)
- Retrospective Studies
- Treatment Outcome
- Wet Macular Degeneration
(drug therapy, epidemiology)
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