miR-212-5p Suppresses Glioma Development via Targeting SUMO2.

Abstract

Recently, increasing studies have suggested that miRNAs play a significant role in the occurrence and development of glioma. More researches are needed to explore the role of miRNAs in glioma, which will help to find new therapeutic targets. miR-212-5p has been reported to be involved in the progression in many cancers. However, whether miR-212-5p has a regulative effect on glioma remains un clear. In this study, we aimed to explore the effect of miR-212-5p on glioma development and its mechanism. Here, we demonstrated that miR-212-5p was lowly expressed in glioma cell. miR-212-5p suppressed the glioma cell proliferation, inhibited the migratory and invasive capabilities and promoted apoptosis in glioma cells. Besides, miR-212-5p also inhibited tumor growth in vivo. We found small ubiquitin-like modifier 2 (SUMO2) was the target of miR-212-5p, and miR-212-5p suppressed SUMO2 expression to regulate the proliferation, migration, and apoptosis of glioma cells. These findings indicated that miR-212-5p may be a possible therapeutic target for the treatment for glioma.

• Authors: Yulong Chong, Chunran Zhu, Wei Hu, Chengrong Jiang, Weibang Liang, Zongjing Zhu
• Journal: Biochemical genetics (Biochem Genet) Vol. 61 Issue 1 Pg. 35-47 (Feb 2023) ISSN: 1573-4927 [Electronic] United States
• PMID: 35715580 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• MicroRNAs
• SUMO2 protein, human
• Small Ubiquitin-Related Modifier Proteins
• MIRN212 microRNA, human

Topics

• Humans
• Glioma (genetics)
• MicroRNAs (genetics, metabolism)
• Cell Proliferation
• Apoptosis
• Cell Line, Tumor
• Gene Expression Regulation, Neoplastic
• Small Ubiquitin-Related Modifier Proteins (metabolism, pharmacology)