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Identification and quantification of N-methylepinephrine in human urine.

Abstract
N-Methylepinephrine was analysed in human urine using a high-performance liquid chromatographic catecholamine assay. The identity of the compound was confirmed by gas chromatography-mass spectrometry. The excretion of N-methylepinephrine is slightly less than that of epinephrine: excretion values were in the range 2-65 nmol per 24 h (0.4-13 micrograms per 24 h) in 150 hypertensive patients. In addition to increased epinephrine excretion, increased urinary excretion of N-methylepinephrine was found in three out of five patients with histologically proven pheochromocytoma.
AuthorsE Gerlo, R Malfait, A G Dupont
JournalJournal of chromatography (J Chromatogr) Vol. 414 Issue 2 Pg. 301-11 (Mar 06 1987) Netherlands
PMID3571398 (Publication Type: Journal Article)
Chemical References
  • N-methylepinephrine
  • Epinephrine
Topics
  • Adrenal Gland Neoplasms (urine)
  • Adult
  • Chromatography, High Pressure Liquid
  • Epinephrine (analogs & derivatives, urine)
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Hypertension (urine)
  • Male
  • Pheochromocytoma (urine)

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