Abstract |
N-Methylepinephrine was analysed in human urine using a high-performance liquid chromatographic catecholamine assay. The identity of the compound was confirmed by gas chromatography-mass spectrometry. The excretion of N-methylepinephrine is slightly less than that of epinephrine: excretion values were in the range 2-65 nmol per 24 h (0.4-13 micrograms per 24 h) in 150 hypertensive patients. In addition to increased epinephrine excretion, increased urinary excretion of N-methylepinephrine was found in three out of five patients with histologically proven pheochromocytoma.
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Authors | E Gerlo, R Malfait, A G Dupont |
Journal | Journal of chromatography
(J Chromatogr)
Vol. 414
Issue 2
Pg. 301-11
(Mar 06 1987)
Netherlands |
PMID | 3571398
(Publication Type: Journal Article)
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Chemical References |
- N-methylepinephrine
- Epinephrine
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Topics |
- Adrenal Gland Neoplasms
(urine)
- Adult
- Chromatography, High Pressure Liquid
- Epinephrine
(analogs & derivatives, urine)
- Gas Chromatography-Mass Spectrometry
- Humans
- Hypertension
(urine)
- Male
- Pheochromocytoma
(urine)
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