HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Immunohistochemical study of nasal mucosa in patients with selective IgA deficiency.

Abstract
Fifteen nasal biopsy specimens from adult patients with selective IgA deficiency were examined in a 'blind' immunohistochemical study for the presence of immunocytes producing various immunoglobulin (Ig) classes. Three groups of patients could be identified. One group had a predominance of IgG- and IgM-producing cells in their nasal mucosa, a second group revealed mainly IgG- and IgD-producing cells, and a third group had very few mucosal immunocytes. The clinical examinations showed that upper respiratory tract infections were most common in patients with few immunocytes while such infections were least common in patients with predominance of IgG and IgM immunocytes. Our results indicated that IgM, in contrast to IgD, acts as a compensatory secretory Ig in some patients with selective IgA deficiency.
AuthorsP Brandtzaeg, G Karlsson, G Hansson, B Petruson, J Björkander, L A Hanson
JournalInternational archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 82 Issue 3-4 Pg. 483-4 ( 1987) ISSN: 0020-5915 [Print] Switzerland
PMID3570518 (Publication Type: Journal Article)
Topics
  • Adolescent
  • Adult
  • Agammaglobulinemia (complications, immunology, pathology)
  • Antibody-Producing Cells (pathology)
  • Disease Susceptibility
  • Female
  • Humans
  • IgA Deficiency
  • Male
  • Middle Aged
  • Nasal Mucosa (immunology, pathology)
  • Respiratory Tract Infections (etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: