Inhibitory effects and gene expression analysis of chemotherapeutic photodynamic therapy by using a liposomally formulated indocyanine green derivative.

Abstract

BACKGROUND:

Photodynamic therapy (PDT) utilizes the enhanced permeability retention effect of photosensitizers and is less invasive and more selective than traditional chemotherapy. We constructed a chemotherapeutic PDT (chemo-PDT) nanoscale drug delivery system using a liposomally formulated indocyanine green derivative (ICG-Lipo) that encapsulated carboplatin and docetaxel (ICG-Lipo-C&D).

METHODS:

The antitumor effect of chemo-PDT mediated by ICG-Lipo-C&D was evaluated in a murine colon 26 CDF1 mouse model. Gene expression in tumor tissues was analyzed by RNA sequencing.

RESULTS:

Chemo-PDT using ICG-Lipo-C&D demonstrated an even stronger PDT-enhancing effect than did ICG-Lipo due to the synergistic effect of carboplatin and docetaxel. In addition, gene expression analysis showed that PDT with ICG-Lipo-C&D increased the expression of immune-related genes and decreased the expression of cytoskeleton-related genes.

CONCLUSIONS:

Chemo-PDT using ICG-Lipo as a photosensitizer as well as a drug delivery system with an enhanced permeability retention effect may be a promising cancer therapy.

• Authors: Yoshiharu Okamoto, Mariko Ishizuka, Fusao Sumiyama, Hisashi Kosaka, Akiko Suganami, Yutaka Tamura, Mitsugu Sekimoto, Masaki Kaibori
• Journal: Photodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 39 Pg. 102961 (Sep 2022) ISSN: 1873-1597 [Electronic] Netherlands
• PMID: 35700912 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Photosensitizing Agents
• Docetaxel
• Carboplatin
• Indocyanine Green

Topics

• Animals
• Carboplatin
• Cell Line, Tumor
• Docetaxel
• Gene Expression
• Indocyanine Green (pharmacology)
• Mice
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)