Chitin-glucan composite sponge hemostat with rapid shape-memory from Pleurotus eryngii for puncture wound.

Abstract

Efficient hemostasis is a great challenge for treating the inaccessible hemorrhage wounds. A novel shape-memory chitin-glucan hemostatic sponge (ATC-Sponge) is constructed via sequentially in-situ removal of protein and glucan from Pleurotus eryngii fruiting body, TEMPO oxidation and Ca2+ crosslinking. The sponge displays interconnected microporous structure with high water absorption and robust mechanical properties. The sponge at dry state shows rapid blood-triggered shape-memory, allowing easy insertion into the puncture wound in a compressed fixed-shape and the subsequent quick volume expansion to conform wound shape to stop bleeding. Compared with standard medical gauze and gelatin sponge, ATC-Sponge demonstrates superior hemostatic performance in the rat femoral artery and non-compressive liver puncture injury models. Additionally, ATC-Sponge can effectively accelerate wound healing. This multi-functional shape-memory ATC-Sponge shows high potential in controlling the bleeding of inaccessible traumas.

• Authors: Caixia Sun, Pengpeng Yue, Runlan Chen, Shuangquan Wu, Qifa Ye, Yunxiang Weng, Haiqing Liu, Yan Fang
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 291 Pg. 119553 (Sep 01 2022) ISSN: 1879-1344 [Electronic] England
• PMID: 35698381 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier Ltd. All rights reserved.

Chemical References

• Glucans
• Hemostatics
• Chitin

Topics

• Animals
• Chitin (pharmacology, therapeutic use)
• Glucans
• Hemorrhage (drug therapy)
• Hemostatics (chemistry, pharmacology, therapeutic use)
• Pleurotus
• Punctures
• Rats