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Influence of ambroxol on tracheobronchial clearance in simple chronic bronchitis.

Abstract
The influence on tracheobronchial clearance of ambroxol, a metabolite of bromhexine, was investigated by measuring the lung retention of inhaled 6 micron monodisperse Teflon particles labelled with 99mTc. Fourteen subjects with simple chronic bronchitis, who belonged to a "responder" group in an earlier study on the subjective effects of ambroxol, were examined using a double-blind cross-over design comparing 120 mg ambroxol daily and placebo. On commencing the study and after each 2-week treatment period, the subjects were examined for mucociliary clearance and clearance by voluntary coughing. Treatment did not influence mucociliary clearance or clearance by cough. There is still a possibility that phlegm loosening by cough is enhanced in situations with more hypersecretion.
AuthorsC H Ericsson, J Juhász, B Mossberg, K Philipson, M Svartengren, P Camner
JournalEuropean journal of respiratory diseases (Eur J Respir Dis) Vol. 70 Issue 3 Pg. 163-70 (Mar 1987) ISSN: 0106-4339 [Print] Denmark
PMID3569448 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ambroxol
  • Bromhexine
Topics
  • Adult
  • Aged
  • Ambroxol (therapeutic use)
  • Bromhexine (analogs & derivatives)
  • Bronchitis (drug therapy)
  • Cilia (drug effects)
  • Double-Blind Method
  • Female
  • Humans
  • Lung (drug effects)
  • Male
  • Microspheres
  • Middle Aged
  • Random Allocation

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