Abstract |
The influence on tracheobronchial clearance of ambroxol, a metabolite of bromhexine, was investigated by measuring the lung retention of inhaled 6 micron monodisperse Teflon particles labelled with 99mTc. Fourteen subjects with simple chronic bronchitis, who belonged to a "responder" group in an earlier study on the subjective effects of ambroxol, were examined using a double-blind cross-over design comparing 120 mg ambroxol daily and placebo. On commencing the study and after each 2-week treatment period, the subjects were examined for mucociliary clearance and clearance by voluntary coughing. Treatment did not influence mucociliary clearance or clearance by cough. There is still a possibility that phlegm loosening by cough is enhanced in situations with more hypersecretion.
|
Authors | C H Ericsson, J Juhász, B Mossberg, K Philipson, M Svartengren, P Camner |
Journal | European journal of respiratory diseases
(Eur J Respir Dis)
Vol. 70
Issue 3
Pg. 163-70
(Mar 1987)
ISSN: 0106-4339 [Print] Denmark |
PMID | 3569448
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Adult
- Aged
- Ambroxol
(therapeutic use)
- Bromhexine
(analogs & derivatives)
- Bronchitis
(drug therapy)
- Cilia
(drug effects)
- Double-Blind Method
- Female
- Humans
- Lung
(drug effects)
- Male
- Microspheres
- Middle Aged
- Random Allocation
|