Guanidino compounds in serum and brain of audiogenically sensitive rats.

Abstract

The levels of 12 guanidino compounds were determined in serum and brain of audiogenically sensitive rats with and without seizures. During audiogenic seizures the serum levels of creatine are significantly decreased, while those of guanidinoacetic acid, N-alpha-acetylarginine, creatinine, gamma-guanidinobutyric acid, arginine, guanidine and methylguanidine are significantly increased. In brain only creatinine and N-alpha-acetylarginine are markedly increased during seizure. These data demonstrate noticeable modifications of the levels of guanidino compounds in the blood during audiogenic seizure and also, in parallel, a creatinine increase in serum and brain.

• Authors: P Wiechert, B Marescau, P De Deyn, A Lowenthal
• Journal: Biomedica biochimica acta (Biomed Biochim Acta) Vol. 45 Issue 10 Pg. 1339-42 ( 1986) ISSN: 0232-766X [Print] Germany
• PMID: 3566723 (Publication Type: Journal Article)

Chemical References

• Guanidines

Topics

• Animals
• Brain Chemistry
• Epilepsy (etiology, metabolism)
• Female
• Guanidines (analysis, blood)
• Male
• Rats
• Rats, Inbred Strains
• Seizures (etiology, metabolism)
• Sound (adverse effects)