Genetic change, particularly epigenetic alteration, is one of the imperative factors for sporadic
breast cancer development in the worldwide population of women. The DNA methylation process is essential and natural for human cellular renewal and tissue homeostasis, but its dysregulation contributes to many pathological changes, including breast
tumorigenesis. Chemopreventive agents mainly protect the abnormal DNA methylation either by hindering the division of pre-malignant cells or looming the DNA damage, which leads to
malignancy. The present review article is about understanding the potential role of
dietary phytochemicals in
breast cancer prevention. Accordingly, a literature search of the published article until August 2021 has been performed. Further, we have investigated the binding affinity of different
phytochemicals isolated from diverse dietary sources against the various oncogenic
proteins related to
breast cancer initiation to understand the common target(s) in
breast cancer prevention mechanisms. Various small
phytochemicals, especially
dietary phytochemicals including
sulforaphane,
mahanine,
resveratrol,
linolenic acid,
diallyl sulfide, benzyl/
phenethyl isothiocyanate, etc. are being investigated as the chemopreventive agent to manage
breast cancer development, and some of them have shown promising outcomes in the cited research. In this present review, we discuss the recent advancement in acceptance of such types of potential
dietary phytochemicals as a chemopreventive agent against
breast cancer development and their inner lining mechanism. The critical clinical trials and cohort studies have also been considered to understand the progress in contemporary perspectives.