Abstract | BACKGROUND: Applying traditional fluorescence navigation technologies in hepatocellular carcinoma is severely restricted by high false-positive rates, variable tumor differentiation, and unstable fluorescence performance. RESULTS: In this study, a green, economical and safe nanomedicine formulation technology was developed to construct carrier-free indocyanine green nanoparticles (nanoICG) with a small uniform size and better fluorescent properties without any molecular structure changes compared to the ICG molecule. Subsequently, nanoICG dispersed into lipiodol via a super-stable homogeneous intermixed formulation technology (SHIFT&nanoICG) for transhepatic arterial embolization combined with fluorescent laparoscopic hepatectomy to eliminate the existing shortcomings. A 52-year-old liver cancer patient was recruited for the clinical trial of SHIFT&nanoICG. We demonstrate that SHIFT&nanoICG could accurately identify and mark the lesion with excellent stability, embolism, optical imaging performance, and higher tumor-to-normal tissue ratio, especially in the detection of the microsatellite lesions (0.4 × 0.3 cm), which could not be detected by preoperative imaging, to realize a complete resection of hepatocellular carcinoma under fluorescence laparoscopy in a shorter period (within 2 h) and with less intraoperative blood loss (50 mL). CONCLUSIONS: This simple and effective strategy integrates the diagnosis and treatment of hepatocellular carcinoma, and thus, it has great potential in various clinical applications.
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Authors | Pan He, Yongfu Xiong, Jinfa Ye, Biaoqi Chen, Hongwei Cheng, Hao Liu, Yating Zheng, Chengchao Chu, Jingsong Mao, Aizheng Chen, Yang Zhang, Jingdong Li, Jie Tian, Gang Liu |
Journal | Journal of nanobiotechnology
(J Nanobiotechnology)
Vol. 20
Issue 1
Pg. 250
(Jun 03 2022)
ISSN: 1477-3155 [Electronic] England |
PMID | 35658966
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Coloring Agents
- Ethiodized Oil
- Indocyanine Green
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Topics |
- Carcinoma, Hepatocellular
(diagnostic imaging, surgery)
- Coloring Agents
- Ethiodized Oil
- Humans
- Indocyanine Green
- Laparoscopy
(methods)
- Liver Neoplasms
(diagnostic imaging, surgery)
- Middle Aged
- Nanoparticles
- Optical Imaging
(methods)
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