Effects of cytochalasin E on H+ and volume secretion in gastric fistula rats.

Abstract

Effects of cytochalasin E on the secretion of H+ and volume of gastric juice were investigated in gastric fistula rats. Direct exposure of the gastric mucosa to cytochalasin E (5-20 micrograms/ml) inhibited H+ secretory rate in all of the pentagastrin-, histamine- as well as non-stimulated rats but it did not affect the secretory volume of gastric juice. The inhibitory action of cytochalasin E on H+ secretion had a rapid onset and showed a dose-dependent pattern. The mechanism of inhibitory action was not related to its interaction with plasma membrane receptors or membrane enzyme, K+-stimulated ATPase. Interference with cellular energy production as well as alteration of microfilament function, which are essential for H+ production and secretion respectively, are likely to be the bases of the cytochalasin inhibition.

• Authors: T Glinsukon, W Suvitayawat, S Sahaphong, P Piyachaturawat
• Journal: Toxicology letters (Toxicol Lett) Vol. 36 Issue 1 Pg. 95-103 (Mar 1987) ISSN: 0378-4274 [Print] Netherlands
• PMID: 3564075 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytochalasins
• cytochalasin E
• Hydrogen

Topics

• Animals
• Cytochalasins (pharmacology)
• Gastric Acid (metabolism)
• Gastric Fistula (physiopathology)
• Gastric Juice (metabolism)
• Gastric Mucosa (drug effects)
• Hydrogen
• Male
• Microscopy, Electron
• Rats
• Rats, Inbred Strains