Abstract |
In the rat, intravenous injection of large doses (30 mg/Kg) of ellagic acid (EA) induced a decrease in the plasma level of fibrinogen and in the blood platelet content and an increase of the activated partial thromboplastin time. The long-lasting thrombocytopenia was inhibited by heparin (4 mg/Kg), defibrase (20 U/Kg), clocoumarol (4 mg/Kg) and CCI 17810 (120 mg/Kg). It was not inhibited by aspirin (90 mg/Kg), indomethacin (8 mg/Kg), ketoprofen (4-10 mg/Kg), epsilon-aminocaproic acid (150 mg/Kg), methysergide (4 mg/Kg), chlorpromazine (10 mg/Kg) and promethazine (4 mg/Kg). On the contrary, the small doses of indomethacin (4 mg/Kg) and of ketoprofen (0.5-2 mg/Kg) increased the thrombopenic effect of EA. EA induced the accumulation of Cr51-labelled platelets into the lungs and the liver, accompanied by a 64% fall in Cr51 blood radioactivity. The platelet stimulating effect of EA would depend on an intravascular coagulation which occurs in the whole cardiovascular system. It is suggested that the pro-aggregating derivatives of arachidonic acid had a minor role in this stimulation. The intravascular coagulation induced by EA was accompanied by a swelling of the lymph nodes and of the spleen. In immune platelet depleted rats, EA induced only the swelling of lymph nodes.
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Authors | J Damas, G Remacle-Volon |
Journal | Thrombosis research
(Thromb Res)
Vol. 45
Issue 2
Pg. 153-63
(Jan 15 1987)
ISSN: 0049-3848 [Print] United States |
PMID | 3563981
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzopyrans
- Pyridazines
- Ellagic Acid
- CCI 17810
- Fibrinogen
- Aspirin
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Topics |
- Animals
- Aspirin
(pharmacology)
- Benzopyrans
(toxicity)
- Blood Platelets
(drug effects)
- Disease Models, Animal
- Ellagic Acid
(antagonists & inhibitors, toxicity)
- Female
- Fibrinogen
(metabolism)
- Male
- Partial Thromboplastin Time
- Pyridazines
(pharmacology)
- Rats
- Rats, Inbred Strains
- Thrombocytopenia
(blood, chemically induced, prevention & control)
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