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The thrombopenic effect of ellagic acid in the rat. Another model of platelet stimulation "in vivo".

Abstract
In the rat, intravenous injection of large doses (30 mg/Kg) of ellagic acid (EA) induced a decrease in the plasma level of fibrinogen and in the blood platelet content and an increase of the activated partial thromboplastin time. The long-lasting thrombocytopenia was inhibited by heparin (4 mg/Kg), defibrase (20 U/Kg), clocoumarol (4 mg/Kg) and CCI 17810 (120 mg/Kg). It was not inhibited by aspirin (90 mg/Kg), indomethacin (8 mg/Kg), ketoprofen (4-10 mg/Kg), epsilon-aminocaproic acid (150 mg/Kg), methysergide (4 mg/Kg), chlorpromazine (10 mg/Kg) and promethazine (4 mg/Kg). On the contrary, the small doses of indomethacin (4 mg/Kg) and of ketoprofen (0.5-2 mg/Kg) increased the thrombopenic effect of EA. EA induced the accumulation of Cr51-labelled platelets into the lungs and the liver, accompanied by a 64% fall in Cr51 blood radioactivity. The platelet stimulating effect of EA would depend on an intravascular coagulation which occurs in the whole cardiovascular system. It is suggested that the pro-aggregating derivatives of arachidonic acid had a minor role in this stimulation. The intravascular coagulation induced by EA was accompanied by a swelling of the lymph nodes and of the spleen. In immune platelet depleted rats, EA induced only the swelling of lymph nodes.
AuthorsJ Damas, G Remacle-Volon
JournalThrombosis research (Thromb Res) Vol. 45 Issue 2 Pg. 153-63 (Jan 15 1987) ISSN: 0049-3848 [Print] United States
PMID3563981 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzopyrans
  • Pyridazines
  • Ellagic Acid
  • CCI 17810
  • Fibrinogen
  • Aspirin
Topics
  • Animals
  • Aspirin (pharmacology)
  • Benzopyrans (toxicity)
  • Blood Platelets (drug effects)
  • Disease Models, Animal
  • Ellagic Acid (antagonists & inhibitors, toxicity)
  • Female
  • Fibrinogen (metabolism)
  • Male
  • Partial Thromboplastin Time
  • Pyridazines (pharmacology)
  • Rats
  • Rats, Inbred Strains
  • Thrombocytopenia (blood, chemically induced, prevention & control)

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