Do enkephalins participate in vagal activation of gastric acid secretion in man?

Abstract

The effects of the anticholinergic drug benzilonium bromide and the opiate receptor blocker naloxone, given alone or in combination, on the acid secretory response and on plasma gastrin releasing peptide (GRP) response to sham feeding was tested in eight duodenal ulcer (DU) patients. Naloxone alone had no effect on the acid secretion after sham feeding. Benzilonium reduced basal acid secretion and the acid response to sham feeding but did not abolish the response. The combination of benzilonium and naloxone was not more effective than benzilonium alone. Neither drug, nor the combination had any effect on plasma GRP following sham feeding. It is concluded that enkephalins are unlikely to participate in the acid response to sham feeding in patients with DU.

• Authors: B Stenquist, T Lind, U Haglund, J J Holst, J F Rehfeld, L Olbe
• Journal: Regulatory peptides (Regul Pept) Vol. 17 Issue 1 Pg. 1-7 (Jan 1987) ISSN: 0167-0115 [Print] Netherlands
• PMID: 3562904 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enkephalins
• Gastrins
• Peptides
• Pyrrolidines
• Naloxone
• Gastrin-Releasing Peptide
• benzilonium bromide

Topics

• Adult
• Duodenal Ulcer (physiopathology)
• Enkephalins (physiology)
• Gastric Juice (metabolism)
• Gastrin-Releasing Peptide
• Gastrins (blood)
• Humans
• Male
• Middle Aged
• Naloxone (pharmacology)
• Peptides (blood)
• Pyrrolidines (pharmacology)
• Stomach (innervation)
• Vagus Nerve (physiology)