The effect of inhaled RS 7540, a xanthone, on exercise-induced asthma.

Abstract

The effect of 71 oxo-7-thiomethoxyxanthone-2-carboxylic acid sodium salt (RS 7540) in inhibiting exercise-induced asthma was compared with that of placebo in a double-blind crossover study. Single doses of 40 mg were given by inhalation to 12 patients. Ten of these subsequently received a dose of 20 mg. RS 7540 at both dose levels had a statistically significant effect in giving total or partial protection from exercise-induced bronchospasm; however, no dose relationship was apparent.

• Authors: B Stenius, Y Salorinne, D Parrott
• Journal: Scandinavian journal of respiratory diseases (Scand J Respir Dis) Vol. 59 Issue 2 Pg. 75-81 (Apr 1978) ISSN: 0036-5572 [Print] Denmark
• PMID: 356252 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Placebos
• Xanthenes

Topics

• Adult
• Asthma (drug therapy)
• Blood Pressure
• Bronchial Spasm (drug therapy, etiology)
• Clinical Trials as Topic
• Double-Blind Method
• Drug Evaluation
• Female
• Heart Rate
• Humans
• Male
• Middle Aged
• Peak Expiratory Flow Rate
• Physical Exertion
• Placebos
• Respiratory Therapy
• Xanthenes (administration & dosage, therapeutic use)