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A study of the anti-inflammatory effect of Voltaren in patients with rheumatoid arthritis.

Abstract
In a double-blind, crossover study conducted in ten hospitalised patients suffering from active rheumatoid arthritis, the anti-inflammatory effect of diclofenac sodium (Voltaren) in a daily dosage of 125 mg was compared with that of placebo under strictly standardised conditions. Changes in reversible articular swelling were determined by measuring the circumference of involved wrist, knee, metacarpophalangeal, interphalangeal, and metatarosphalangeal joints. A consistent decrease in joint swelling occurred in response to treatment with diclofenac sodium, as compared with a consistent increase following placebo medication. This difference was significant at the 5% level for all except the interphalangeal joints. Similarly, in response to diclofenac sodium a greater improvement was noted in duration of morning stiffness and grip strength and a greater reduction in the total number of painful and swollen joints. The status of the rheumatoid condition improved in nine patients following treatment with diclofenac sodium, but in none following placebo medication. Two patients reported unwanted effects, consisting of a sensation of fullness during treatment with diclofenac sodium in one case and of heartburn during both treatment periods in the other. No laboratory abnormalities were noted.
AuthorsA Bijlsma, J G ten Pas
JournalScandinavian journal of rheumatology. Supplement (Scand J Rheumatol Suppl) Issue 22 Pg. 46-50 ( 1978) ISSN: 0301-3847 [Print] SWEDEN
PMID356245 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Phenylacetates
  • Placebos
  • Diclofenac
Topics
  • Administration, Oral
  • Adult
  • Arthritis, Rheumatoid (drug therapy)
  • Clinical Trials as Topic
  • Diclofenac (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Drug Evaluation
  • Female
  • Humans
  • Knee Joint (drug effects)
  • Male
  • Metacarpophalangeal Joint (drug effects)
  • Metatarsophalangeal Joint (drug effects)
  • Middle Aged
  • Phenylacetates (therapeutic use)
  • Placebos
  • Wrist Joint (drug effects)

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