Abstract |
The ability of various compounds to antagonise the 5-MeODMT induced prolongations of latency and duration of postdecapitation convulsions (PDCs) were compared. The 5-hydroxytryptamine (5-HT) receptor antagonists, mianserin, methergoline, cinanserin and methysergide antagonised the 5-MeODMT (0.5 to 4.0 mg/kg) induced prolongations of latency to onset of convulsions substantially and to a lesser extent the prolongation of duration. The efficacy of the 5-HT antagonists for blocking 5-MeODMT changes of PDCs was roughly of the order mianserin greater than cinanserin greater than methysergide greater than methergoline. Pirenperone, the 5-HT2 antagonist, and pimozide, the dopamine receptor antagonist did not antagonise the 5-MeODMT induced changes. Mianserin, methergoline, cinanserin and methysergide, by themselves, prolonged the duration of PDCs but did not affect latency. Pirenperone (0.25 mg/kg) prolonged both the latency and duration of the PDCs while pimozide (0.5-2.0 mg/kg) had no effect upon PDCs. This evidence suggests that 5-MeODMT induced changes of PDCs are mediated via 5-HT1 receptors and thus a reliable model to combine with other measures of spinal function is suggested.
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Authors | T Archer |
Journal | Pharmacology & toxicology
(Pharmacol Toxicol)
Vol. 60
Issue 1
Pg. 37-42
(Jan 1987)
ISSN: 0901-9928 [Print] Denmark |
PMID | 3562388
(Publication Type: Journal Article)
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Chemical References |
- Methoxydimethyltryptamines
- Serotonin Antagonists
- Serotonin
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Topics |
- Animals
- Decerebrate State
- Male
- Mesencephalon
(physiopathology)
- Methoxydimethyltryptamines
(pharmacology)
- Rats
- Rats, Inbred Strains
- Seizures
(physiopathology, prevention & control)
- Serotonin
(analogs & derivatives)
- Serotonin Antagonists
(pharmacology)
- Spinal Cord
(physiopathology)
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