5-Hydroxytryptamine antagonists and the 5-methoxy-N,N-dimethyltryptamine-induced changes of postdecapitation convulsions.

Abstract

The ability of various compounds to antagonise the 5-MeODMT induced prolongations of latency and duration of postdecapitation convulsions (PDCs) were compared. The 5-hydroxytryptamine (5-HT) receptor antagonists, mianserin, methergoline, cinanserin and methysergide antagonised the 5-MeODMT (0.5 to 4.0 mg/kg) induced prolongations of latency to onset of convulsions substantially and to a lesser extent the prolongation of duration. The efficacy of the 5-HT antagonists for blocking 5-MeODMT changes of PDCs was roughly of the order mianserin greater than cinanserin greater than methysergide greater than methergoline. Pirenperone, the 5-HT2 antagonist, and pimozide, the dopamine receptor antagonist did not antagonise the 5-MeODMT induced changes. Mianserin, methergoline, cinanserin and methysergide, by themselves, prolonged the duration of PDCs but did not affect latency. Pirenperone (0.25 mg/kg) prolonged both the latency and duration of the PDCs while pimozide (0.5-2.0 mg/kg) had no effect upon PDCs. This evidence suggests that 5-MeODMT induced changes of PDCs are mediated via 5-HT1 receptors and thus a reliable model to combine with other measures of spinal function is suggested.

• Authors: T Archer
• Journal: Pharmacology & toxicology (Pharmacol Toxicol) Vol. 60 Issue 1 Pg. 37-42 (Jan 1987) ISSN: 0901-9928 [Print] Denmark
• PMID: 3562388 (Publication Type: Journal Article)

Chemical References

• Methoxydimethyltryptamines
• Serotonin Antagonists
• Serotonin

Topics

• Animals
• Decerebrate State
• Male
• Mesencephalon (physiopathology)
• Methoxydimethyltryptamines (pharmacology)
• Rats
• Rats, Inbred Strains
• Seizures (physiopathology, prevention & control)
• Serotonin (analogs & derivatives)
• Serotonin Antagonists (pharmacology)
• Spinal Cord (physiopathology)