Abstract | BACKGROUND: METHODS: This prospective study enrolled 35 patients with CADASIL (59 eyes) and 35 healthy controls (54 eyes). OCT-A was used to measure the vessel density of the macular region and the thickness of retinal layers. Patients with CADASIL were divided into stroke (n = 20) and nonstroke (n = 15) subgroups and underwent cognition and gait speed evaluation. Neuroimaging markers of cortical thickness, white matter hyperintensity, lacunae, and cerebral microbleeds were examined through brain magnetic resonance imaging. RESULTS: The OCT-A parameters, including vessel density, were comparable between the patients with CADASIL and the controls. In patients with CADASIL, vessel density in the superficial retinal plexus in the macula as was inner retinal thickness was significantly lower in the stroke than the nonstroke subgroup. Macular vessel density and inner retinal thickness were positively correlated with gait speed, while negatively correlated with number of lacunae. CONCLUSIONS: OCT-A is potentially a useful tool for evaluating disease severity, ischaemic burden, and neurodegeneration in patients with advanced CADASIL.
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Authors | Chao-Wen Lin, Zih-Wei Yang, Chih-Hao Chen, Yu-Wen Cheng, Sung-Chun Tang, Jiann-Shing Jeng |
Journal | PloS one
(PLoS One)
Vol. 17
Issue 5
Pg. e0268572
( 2022)
ISSN: 1932-6203 [Electronic] United States |
PMID | 35617208
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Humans
- CADASIL
(pathology)
- Cerebral Infarction
- Leukoencephalopathies
- Magnetic Resonance Imaging
- Prospective Studies
- Receptor, Notch3
(genetics)
- Stroke
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