Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions.

Abstract

A 30-year-old man admitted with renal dysfunction (serum creatinine, 8.19 mg/dL) was diagnosed with immunoglobulin A nephritis through a renal biopsy. He was treated with intravenous methylprednisolone pulse therapy and urgent hemodialysis, and eventually, he underwent maintenance hemodialysis. On day 108, he developed amnesia. Magnetic resonance imaging revealed bilateral basal ganglia lesions. Wernicke encephalopathy (WE) was diagnosed based on decreased serum thiamine concentration (12.8 μg/dL; reference range, 24-66 μg/dL). Thiamine replacement therapy was initiated, but the Wernicke-Korsakoff syndrome persisted. Careful monitoring of thiamine is required in patients undergoing dialysis. In addition, patients with WE may exhibit bilateral basal ganglia lesions.

• Authors: Masaoki Hidaka, Masaya Kumamoto, Tatsuya Suenaga, Ayaka Itsuji, Yuka Kanazawa, Seiji Goto, Hitonori Takaba, Takanari Kitazono
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 62 Issue 1 Pg. 113-118 (Jan 01 2023) ISSN: 1349-7235 [Electronic] Japan
• PMID: 35598991 (Publication Type: Case Reports, Journal Article)

Chemical References

• Thiamine

Topics

• Male
• Humans
• Young Adult
• Adult
• Renal Dialysis (adverse effects)
• Korsakoff Syndrome
• Wernicke Encephalopathy (diagnosis, etiology)
• Thiamine Deficiency
• Thiamine (therapeutic use)
• Ganglia