Rare antibody-mediated and seronegative autoimmune encephalitis: An update.

Abstract

Paralleling advances with respect to more common antibody-mediated encephalitides, such as anti-N-methyl-D-aspartate receptor (NMDAR) and anti-leucine-rich glioma-inactivated 1 (LGI1) Ab-mediated encephalitis, the discovery and characterisation of novel antibody-mediated encephalitides accelerated over the past decade, adding further depth etiologically to the spectrum of antibody-mediated encephalitis. Herein, we review the major mechanistic, clinical features and management considerations with respect to anti-γ-aminobutyric acid B (GABAB)-, anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropinoic receptor- (AMPAR), anti-GABAA-, anti-dipeptidyl-peptidase-like protein-6 (DPPX) Ab-mediated encephalitides, delineate rarer subtypes and summarise findings to date regarding seronegative autoimmune encephalitis.

• Authors: Nabil Seery, Helmut Butzkueven, Terence J O'Brien, Mastura Monif
• Journal: Autoimmunity reviews (Autoimmun Rev) Vol. 21 Issue 7 Pg. 103118 (Jul 2022) ISSN: 1873-0183 [Electronic] Netherlands
• PMID: 35595048 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• Proteins

Topics

• Anti-N-Methyl-D-Aspartate Receptor Encephalitis
• Autoantibodies
• Encephalitis (diagnosis)
• Hashimoto Disease (diagnosis)
• Humans
• Proteins