Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo.

Abstract

The antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC50, 1.5 microgram/ml) and L1210 murine leukemia cells (IC50, 2.2 micrograms/ml). Acetomycin also had marked activity in the human tumor stem cell assay, with a 33% overall response rate (less than or equal to 30% survival) against 49 primary tumors. However, acetomycin was inactive in four in vivo tumor assay systems (L1210 and P388 leukemias, B16 melanoma and the MX-1 mammary xenograft system). This lack of in vivo activity may result from metabolic inactivation of acetomycin.

• Authors: S W Mamber, J D Mitulski, K L Hamelehle, J C French, G C Hokanson, J L Shillis, W R Leopold, D D Von Hoff, J B Tunac
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 40 Issue 1 Pg. 73-6 (Jan 1987) ISSN: 0021-8820 [Print] England
• PMID: 3558118 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Furans
• acetomycin

Topics

• Adenocarcinoma
• Animals
• Antibiotics, Antineoplastic (therapeutic use)
• Cell Line
• Cell Survival (drug effects)
• Colonic Neoplasms
• Furans (pharmacology, therapeutic use)
• Humans
• Leukemia L1210 (drug therapy)
• Mice
• Tumor Stem Cell Assay