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Liver levels of vitamin A and cellular retinol-binding protein for patients with biliary atresia.

Abstract
We have examined whether the amount of cellular retinol-binding protein in human liver is related to the amount of vitamin A stored in the liver. Levels of vitamin A, as retinol and retinol esters, and of cellular retinol-binding protein have been determined in liver samples from 6 normal adults and 11 children with biliary atresia, with and without vitamin A treatment. The level of cellular retinol-binding protein in the liver was not related to the liver vitamin A concentration examined over a 300-fold range of vitamin A levels. Also, biliary atresia did not appear to interfere with storage of vitamin A, and the level of cellular retinol-binding protein was comparable to that observed in the liver of normal adults. The demonstration of proper vitamin A storage in treated children as well as normal levels of cellular retinol-binding protein suggest the vitamin A deficiency frequently observed in children with biliary atresia may be due primarily to faulty absorption rather than a combination of poor absorption and impaired hepatic vitamin A metabolism.
AuthorsD E Ong, O Amédée-Manesme
JournalHepatology (Baltimore, Md.) (Hepatology) 1987 Mar-Apr Vol. 7 Issue 2 Pg. 253-6 ISSN: 0270-9139 [Print] United States
PMID3557304 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Retinol-Binding Proteins
  • Retinol-Binding Proteins, Cellular
  • Vitamin A
Topics
  • Biliary Atresia (metabolism)
  • Humans
  • Infant
  • Liver (metabolism)
  • Retinol-Binding Proteins (metabolism)
  • Retinol-Binding Proteins, Cellular
  • Vitamin A (metabolism)

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