HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Embryotoxicity and fetotoxicity of orally administered tridiphane in mice and rats.

Abstract
Tridiphane [2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane], a broad-leaf herbicide, was evaluated for its potential effects on mouse and rat embryonal and fetal development. Pregnant CF-1 mice were given 0, 25, 75, or 250 mg tridiphane/kg/day on Days 6 through 15 of gestation. Significant maternal toxicity was observed in both the 75- and 250-mg/kg/day dose groups. An increased percentage of females given 250 mg/kg/day showed implantation sites only after staining of the uterus, suggesting a toxic effect on the embryo during the early stages of development, possibly secondary to maternal toxicity. Increases in some skeletal variants were noted at the 75-mg/kg dose level; however, a teratogenic effect was not observed. An additional group of mice was given 250 mg/kg/day on Days 8 through 15 of gestation. Maternal toxicity was also observed among these mice as manifested by significantly elevated (+50%) liver weight; however, there was a substantial increase in the number of females with full-term litters following this shorter dosing period. An increase in the occurrence of cleft palate in these offspring associated with low fetal body weights was also observed. Pregnant Sprague-Dawley rats were given 0, 30, 100, or 200 mg/kg/day of tridiphane on Days 6 through 15 of gestation. Maternal toxicity was observed among rats given 200 mg/kg. Increased incidences of two minor skeletal variants, lumbar spurs and extra ribs, were observed in the 200-mg/kg/day dose group, and an increase in lumbar spurs was observed at 100 mg/kg/day. Thus, tridiphane was embryotoxic and induced cleft palate in mice only at the maternally toxic dose level of 250 mg/kg/day.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsT R Hanley Jr, J A John-Greene, W C Hayes, K S Rao
JournalFundamental and applied toxicology : official journal of the Society of Toxicology (Fundam Appl Toxicol) Vol. 8 Issue 2 Pg. 179-87 (Feb 1987) ISSN: 0272-0590 [Print] UNITED STATES
PMID3556830 (Publication Type: Journal Article)
Chemical References
  • Epoxy Compounds
  • Ethers, Cyclic
  • Teratogens
  • tridiphane
Topics
  • Abnormalities, Drug-Induced (pathology)
  • Administration, Oral
  • Animals
  • Body Weight (drug effects)
  • Embryo, Mammalian (drug effects)
  • Epoxy Compounds (administration & dosage, toxicity)
  • Ethers, Cyclic (toxicity)
  • Female
  • Fetal Death
  • Fetal Resorption
  • Fetus (drug effects)
  • Liver (drug effects, pathology)
  • Mice
  • Organ Size (drug effects)
  • Pregnancy
  • Teratogens (toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: