Embryotoxicity and fetotoxicity of orally administered tridiphane in mice and rats.

Tridiphane [2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane], a broad-leaf herbicide, was evaluated for its potential effects on mouse and rat embryonal and fetal development. Pregnant CF-1 mice were given 0, 25, 75, or 250 mg tridiphane/kg/day on Days 6 through 15 of gestation. Significant maternal toxicity was observed in both the 75- and 250-mg/kg/day dose groups. An increased percentage of females given 250 mg/kg/day showed implantation sites only after staining of the uterus, suggesting a toxic effect on the embryo during the early stages of development, possibly secondary to maternal toxicity. Increases in some skeletal variants were noted at the 75-mg/kg dose level; however, a teratogenic effect was not observed. An additional group of mice was given 250 mg/kg/day on Days 8 through 15 of gestation. Maternal toxicity was also observed among these mice as manifested by significantly elevated (+50%) liver weight; however, there was a substantial increase in the number of females with full-term litters following this shorter dosing period. An increase in the occurrence of cleft palate in these offspring associated with low fetal body weights was also observed. Pregnant Sprague-Dawley rats were given 0, 30, 100, or 200 mg/kg/day of tridiphane on Days 6 through 15 of gestation. Maternal toxicity was observed among rats given 200 mg/kg. Increased incidences of two minor skeletal variants, lumbar spurs and extra ribs, were observed in the 200-mg/kg/day dose group, and an increase in lumbar spurs was observed at 100 mg/kg/day. Thus, tridiphane was embryotoxic and induced cleft palate in mice only at the maternally toxic dose level of 250 mg/kg/day.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsT R Hanley Jr, J A John-Greene, W C Hayes, K S Rao
JournalFundamental and applied toxicology : official journal of the Society of Toxicology (Fundam Appl Toxicol) Vol. 8 Issue 2 Pg. 179-87 (Feb 1987) ISSN: 0272-0590 [Print] UNITED STATES
PMID3556830 (Publication Type: Journal Article)
Chemical References
  • Epoxy Compounds
  • Ethers, Cyclic
  • Teratogens
  • tridiphane
  • Abnormalities, Drug-Induced (pathology)
  • Administration, Oral
  • Animals
  • Body Weight (drug effects)
  • Embryo, Mammalian (drug effects)
  • Epoxy Compounds (administration & dosage, toxicity)
  • Ethers, Cyclic (toxicity)
  • Female
  • Fetal Death
  • Fetal Resorption
  • Fetus (drug effects)
  • Liver (drug effects, pathology)
  • Mice
  • Organ Size (drug effects)
  • Pregnancy
  • Teratogens (toxicity)

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