Activation of distinct helper and suppressor T cells in experimental trypanosomiasis.

Abstract

Spleen cells taken from mice soon after infection with Trypanosoma brucei S 42 enhance the primary in vitro antibody response of normal spleen cells to sheep red blood cells (SRBC), but do not affect their response to DNP-Ficoll. Spleen cells harvested later in the infection (day 6 onwards) suppress the antibody response of normal spleen cells to both SRBC and DNP-Ficoll. The enhancing and suppressive effects of "infected" spleen cells are sensitive to treatment with anti-Thy 1.2 anti-serum and complement, and can be mediated by nylon wool-purified populations of T cells. The enhancing T cell is sensitive to ALS, not lost within 4 weeks of adult thymectomy, and bears the Ly-1+, 23- phenotype. The suppressor T cell is insensitive to ALS, lost within 20 weeks of adult thymectomy, and bears the Ly-1+, 23+ phenotype. The significance of the activation of distinct helper and suppressor T cells is discussed in relation to the pathogenesis of trypanosomiasis.

• Authors: A N Jayawardena, B H Waksman, D D Eardley
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 121 Issue 2 Pg. 622-8 (Aug 1978) ISSN: 0022-1767 [Print] United States
• PMID: 355549 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antilymphocyte Serum

Topics

• Animals
• Antilymphocyte Serum (pharmacology)
• Cattle
• Hemolytic Plaque Technique
• Immunosuppression Therapy
• Lymphocyte Cooperation
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• T-Lymphocytes (immunology)
• Thymectomy
• Trypanosoma brucei brucei (immunology)
• Trypanosomiasis, Bovine (immunology)