Abstract |
The presently available data on pharmacokinetics of halogenated solvents which produce hepatic tumors in B6C3F1 mice, but not in rats, are reviewed. Such compounds are trichloroethylene, perchloroethylene, 1,1,2-trichloroethane, 1,1,2,2-tetrachloroethane, and dichloromethane. It seems likely that higher metabolic rates in mice (compared with other species) may lead to a species-selective toxicity of such compounds. Recurrent cytotoxicity which leads to stimulation of cell replication seems to be a contributing factor in the pathogenesis of mouse liver tumors. However, it is likely that more than one factor contributes to the unique tumor response of the B6C3F1 mouse.
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Authors | H M Bolt |
Journal | Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
(Arch Toxicol Suppl)
Vol. 10
Pg. 190-203
( 1987)
ISSN: 0171-9750 [Print] Germany |
PMID | 3555414
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Hydrocarbons, Chlorinated
- Hydrocarbons, Halogenated
- Trichloroethanes
- 1,1,2,2-tetrachloroethane
- 1,1,2-trichloroethane
- Trichloroethylene
- Methylene Chloride
- Ethane
- Tetrachloroethylene
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Topics |
- Animals
- Ethane
(analogs & derivatives, metabolism)
- Hydrocarbons, Chlorinated
(metabolism)
- Hydrocarbons, Halogenated
(metabolism, toxicity)
- Kinetics
- Liver Neoplasms, Experimental
(chemically induced)
- Methylene Chloride
(metabolism)
- Mice
- Species Specificity
- Tetrachloroethylene
(metabolism)
- Trichloroethanes
(metabolism)
- Trichloroethylene
(metabolism)
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