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Clinical efficacy of ciprofloxacin in the treatment of patients with respiratory tract infections in Japan.

AbstractThe clinical efficacy, safety, and optimal dosage of oral ciprofloxacin for the treatment of respiratory infections were studied in a multicenter, open trial in Japan. Five hundred seventy-one patients with respiratory infections received orally administered ciprofloxacin (the majority received 600 mg daily). Clinical efficacy was evaluated in 542 of these patients, and safety was analyzed in 568 patients. Clinical efficacy was excellent or good in 80.9 percent of patients with pneumonia, and in 71.3 percent of patients with chronic airway infections. The overall bacteriologic eradication rate was 68.5 percent. In infections caused by Hemophilus influenzae, the rate was 90.8 percent. Side effects were observed in 4.6 percent of patients, and abnormal laboratory findings were noted in 6.9 percent; however, there were no severe reactions. Ciprofloxacin may be a very useful agent for the treatment of respiratory infections.
AuthorsH Kobayashi
JournalThe American journal of medicine (Am J Med) Vol. 82 Issue 4A Pg. 169-73 (Apr 27 1987) ISSN: 0002-9343 UNITED STATES
PMID3555031 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Ciprofloxacin
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Ciprofloxacin (administration & dosage, adverse effects, therapeutic use)
  • Clinical Trials as Topic
  • Digestive System (drug effects)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pneumonia (drug therapy)
  • Respiratory Tract Infections (drug therapy)