Amino-sugars inhibit the in vitro cytoadherence of Plasmodium falciparum-infected erythrocytes to melanoma cells.

Abstract

Twenty-two sugars and related compounds, nine neoglycoproteins, dopamine, four polyamines and oligomers of glucosamine were examined for their effect on the cytoadherence of Plasmodium falciparum-infected erythrocytes to melanoma cells. Inhibition of cytoadherence was high in the presence of the amino-sugars, glucosamine, galactosamine and mannosamine, and dopamine, and significant, although lower, in the presence of the polyamines, spermine, spermidine and putrescine. N-acetylated amino-sugars and the other compounds were not significant inhibitors of cytoadherence.

• Authors: B Singh, M Monsigny, M Hommel
• Journal: Molecular and biochemical parasitology (Mol Biochem Parasitol) Vol. 23 Issue 1 Pg. 47-53 (Feb 1987) ISSN: 0166-6851 [Print] Netherlands
• PMID: 3553937 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amino Sugars
• Polyamines
• Glucosamine

Topics

• Amino Sugars (pharmacology)
• Animals
• Cell Adhesion (drug effects)
• Cell Line
• Erythrocytes (drug effects, parasitology, physiology)
• Female
• Glucosamine (pharmacology)
• Humans
• Melanoma
• Plasmodium falciparum (physiology)
• Polyamines (pharmacology)
• Saimiri