Programmed
necrosis,a mode of cell death independent of
Caspase,is mainly mediated by receptor-interacting
protein kinase-1 (RIPK1),receptor-interacting
protein kinase-3 (RIPK3),and mixed lineage
kinase domain-like
protein (MLKL).Studies have demonstrated that programmed
necrosis has the dual role of promoting and inhibiting
tumor growth and thus we can control the development of
tumor by regulating programmed
necrosis.The drugs capable of inducing programmed
necrosis show potential anti-
tumor activity.In addition,inducing programmed
necrosis is an effective way to overcome
tumor resistance to apoptosis.This paper summarized the mechanisms of programmed
necrosis and its relationship with
tumors.We focused on the antitumor activity of programmed
necrosis inducers including natural products,chemotherapeutic drugs,
death receptor ligands,
kinase inhibitors,inorganic
salts,
metal complexes,and metal nanoparticles.These agents will provide new therapeutic candidates for the treatment of
tumors,especially the
tumors acquiring resistance to apoptosis.