[Role of the ES-62 protein derived from Acanthocheilonema viteae in regulation of immune dysregulation diseases: a review].

Abstract

ES-62 is a phosphorylcholine-containing, 62 kDa glycoprotein derived from the excretory-secretory product of Acanthocheilonema viteae, which is effective for the prevention and treatment of immune dysregulation diseases through triggering activation of immune cells, such as dendritic cells, mononuclear macrophages and regulatory B cells and mediating immune responses. Recently, the role of the ES-62 protein in the management of allergic, autoimmune and metabolic diseases has been paid much attention. This review summarizes the regulatory role of the ES-62 protein in immune dysregulation diseases and the underlying mechanisms, so as to provide insights into future experimental studies.

• Authors: Q Hu, J Y Xing, P Wu, T T Huang, X D Yang
• Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control (Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi) Vol. 34 Issue 2 Pg. 204-211 (Nov 01 2021) ISSN: 1005-6661 [Print] China
• PMID: 35537846 (Publication Type: Journal Article, Review)

Chemical References

• Glycoproteins
• Helminth Proteins
• Phosphorylcholine

Topics

• Acanthocheilonema (metabolism)
• Animals
• Dipetalonema (metabolism)
• Glycoproteins
• Helminth Proteins
• Phosphorylcholine (metabolism)