A randomized study of two schedules of copovithane in patients with advanced colorectal carcinoma.

Abstract

Copovithane (BAY i 7433), a copolymer of 1,3-bis(methylaminocarboxyl)-2-methylenepropanecarbamate and N-vinyl pyrrolidone, has antitumor activity in vitro and in vivo. The mechanism of this polymer is unknown. Thirty patients with advanced colorectal carcinoma with measurable tumors were treated in an open randomized study with two schedules of copovithane (schedule A: 6 g/m2 i.v. over 30 min daily for 5 consecutive days and repeated every 3 weeks; schedule B: 10 g/m2 i.v. over 30 min once a week until progression, unacceptable toxicity, or up to 18 months). Fifteen patients received copovithane on a weekly schedule, and 15 patients received it on an intermittent schedule. None of the patients on either schedule achieved a complete or partial remission. Copovithane was ineffective against colorectal carcinoma by both schedules selected in this study.

• Authors: J A Ajani, G N Hortobagyi, D Frye, B Levin, B M Boman, J S Faintuch
• Journal: American journal of clinical oncology (Am J Clin Oncol) Vol. 10 Issue 2 Pg. 139-40 (Apr 1987) ISSN: 0277-3732 [Print] United States
• PMID: 3551577 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Carbamates
• copovithane
• Povidone

Topics

• Antineoplastic Agents (administration & dosage, adverse effects)
• Carbamates (administration & dosage, adverse effects)
• Carcinoma (drug therapy)
• Clinical Trials as Topic
• Colonic Neoplasms (drug therapy)
• Humans
• Povidone (administration & dosage, adverse effects)
• Random Allocation
• Rectal Neoplasms (drug therapy)