[Therapeutic trials of aclarubicin in previously treated acute leukemias and hematosarcomas].

Abstract

In a phase I-II trial, 38 patients with acute myeloid leukemia (AML) were given single drug induction therapy with aclarubicin (ACM) according to two dosing schedules: treatment 1: 10 to 30 mg/m2/d to a maximum total dose of 300 mg/m2 or until development of unacceptable toxicity: treatment 2: 15 mg/m2/d in ten-day courses separated by ten-day intervals. Response rates were 15% with treatment 1 and 44% with treatment 2 (overall response rate 34%). Complete remission (CR) was achieved in 6 patients who had previously failed to respond to adriamycin (ADM). Toxicity was more frequent and more severe in those patients given more than 150 mg/m2 ACM per course. The main side effects were oropharyngeal mucositis and diarrhea. Three patients exhibited T wave inversion and one had an episode of auricular flutter. In a separate trial in 16 patients with AML we used cyclic chemotherapy combining ACM (20 mg/m2/d) and ARA-C (200 mg/m2/d) for seven consecutive days. Complete remission rate was 50%. Severe ventricular rhythm disorders were seen in two patients. In a phase I-II study, 19 patients with acute lymphoid leukemia (ALL) and 8 patients with non-Hodgkin lymphoma (NHL) were given ACM alone according to the regimen designated treatment 1 described above. Response rates were 11% (2/19) in ALL and 25% (2/8) in NHL. A review of the literature is presented in the discussion of the original trials reported herein.

• Authors: D Machover, E Goldschmidt, M Benavides, J Gastiaburu, J M Vandenbulcke, M Delgado, J L Misset, G Mathe
• Journal: Pathologie-biologie (Pathol Biol (Paris)) Vol. 35 Issue 1 Pg. 79-86 (Jan 1987) ISSN: 0369-8114 [Print] France
• Vernacular Title: Essais thérapeutiques de l'aclarubicine dans les leucémies aiguës et les hématosarcomes antérieurement traités.
• PMID: 3550616 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Naphthacenes
• Cytarabine
• Aclarubicin

Topics

• Aclarubicin
• Adolescent
• Adult
• Aged
• Antibiotics, Antineoplastic (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Cytarabine (therapeutic use)
• Drug Evaluation
• Female
• Humans
• Leukemia, Lymphoid (drug therapy)
• Leukemia, Myeloid, Acute (drug therapy)
• Lymphoma, Non-Hodgkin (drug therapy)
• Male
• Middle Aged
• Naphthacenes (therapeutic use)