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Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae.

Abstract
To evaluate the antisecretory activity of berberine sulfate (BS), we studied 165 adult patients with acute diarrhea due to enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae in randomized controlled trials. In patients with ETEC diarrhea who received 400 mg of BS in a single oral dose, the mean stool volumes were significantly less than those of the controls during three consecutive 8-hr periods after treatment (P less than .05). At 24 hr after treatment, significantly more patients who were treated with BS and had ETEC diarrhea stopped having diarrhea as compared with the controls (42% vs 20%, P less than .05). In patients with cholera who received 400 mg of BS, the mean 8-hr stool volume during the second 8-hr period after treatment declined to 2.22 liters, which was significantly less than the 2.79 liters found in the controls (P less than .05). However, patients with cholera who received 1200 mg of BS plus tetracycline did not have significant reduction in stool output compared with patients who received tetracycline alone. No side effects of BS were noted. These results indicated that BS is an effective and safe antisecretory drug for ETEC diarrhea, whereas the activity against cholera is slight and not additive with tetracycline.
AuthorsG H Rabbani, T Butler, J Knight, S C Sanyal, K Alam
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 155 Issue 5 Pg. 979-84 (May 1987) ISSN: 0022-1899 [Print] UNITED STATES
PMID3549923 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Bacterial Toxins
  • Berberine Alkaloids
  • Enterotoxins
  • Escherichia coli Proteins
  • heat stable toxin (E coli)
  • heat-labile enterotoxin, E coli
  • Berberine
  • Tetracycline
Topics
  • Adult
  • Bacterial Toxins (biosynthesis)
  • Berberine (therapeutic use)
  • Berberine Alkaloids (therapeutic use)
  • Cholera (drug therapy)
  • Clinical Trials as Topic
  • Diarrhea (drug therapy, etiology)
  • Drug Therapy, Combination
  • Enterotoxins (biosynthesis)
  • Escherichia coli (metabolism)
  • Escherichia coli Infections (drug therapy)
  • Escherichia coli Proteins
  • Humans
  • Male
  • Random Allocation
  • Tetracycline (therapeutic use)

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