Piracetam in alcoholic organic mental disorder: a placebo controlled study comparing two dosages.

Abstract

The following paper presents an investigation of the efficacy of piracetam in alcoholic organic mental disorder. A double-blind placebo-controlled study design was used to compare 2 dosages of the substance (2 X 3 g vs. 2 X 12 g). Cognitive function was assessed on days 0, 7, 14, 28, 42. Analysis of the results from 24 patients showed a clear-cut amelioration of cognitive functions in all 3 treatment groups. No difference could be demonstrated between the administration of placebo and the lower dose of piracetam. Patients on the higher dose showed an earlier improvement on one of the tests, but the final scores were similar in all three treatment groups.

• Authors: W W Fleischhacker, V Günther, C Barnas, F Lieder, C Miller
• Journal: International clinical psychopharmacology (Int Clin Psychopharmacol) Vol. 1 Issue 3 Pg. 210-5 (Jul 1986) ISSN: 0268-1315 [Print] England
• PMID: 3549872 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Placebos
• Pyrrolidinones
• Piracetam

Topics

• Adult
• Alcoholism (complications)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Piracetam (administration & dosage, therapeutic use)
• Placebos
• Pyrrolidinones (administration & dosage)
• Substance-Related Disorders (drug therapy)