The PLAC8 expression in
lung cancer tissues and in vitro grown
lung cancer cells, as well as the involvement of the Wnt/β-
Catenin signaling pathway, was investigated in this process. PLAC8
protein expression in human
lung cancer tissues and lung
tumor cells of different strains was discovered using immunohistochemistry staining and Western blot, respectively. Animal models of PLAC8 overexpression and knockdown were created using lentivirus. The development in
tumor tissue was seen both in vitro and vivo. The Wnt/β-
Catenin signaling pathway played an important part in this process, as shown by the dual
luciferase reporter gene system. PLAC8 expression was elevated in
lung cancer tissues and plasma and decreased in plasma after lung
tumor resection. PLAC8 upregulation promotes cell proliferation in vivo and in vitro, while PLAC8 downregulation inhibits cell viability and proliferation. The results of the dual
luciferase reporter gene system suggest that PLAC8 can significantly activate the Wnt/β-
Catenin signaling pathway in cells and can conduct signaling through it. A potential treatment targeting the prognosis of
lung cancer patients may be PLAC8 overexpression, which promotes the
lung cancer cell proliferation through controlling the Wnt/β-
Catenin signaling pathway.