[Antibody Sustainability in SARS-CoV-2 Healthcare Professionals' Patient Cohort].

Abstract

In this study, it was aimed to evaluate one-year follow-up of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) specific antibodies formed against the virus binding site, in a coronavirus disease-2019 (COVID-19) positive case cohort (n= 413) between the period March 2020 to December 2020 in Manisa Celal Bayar University Hospital, until July 2021. SARS-CoV-2 antibodies were determined by the chemiluminescent enzyme immunoassay (CLIA) method. Values of 1.0 and above were considered positive. Chi-square tests and Joinpoint regression analysis (version 4.7.0) were used in the statistical analyses. The mean age of the participants was 34.9 ± 9.3 and 60.2% of them were women. Between 21-30 days after the diagnosis of COVID-19, total antibody level was above the threshold value in 72.2% (n= 126) of the participants, while this rate increased to 79.1% (n= 240) in 31-60 day interval. In the following period, this rate decreased to 38.8% (n= 108) in days 211st to 240th. Antibody response could not be detected in 76 (20.7%) of 367 employees who have initially been followed up. The percentage of total antibody positivity prevalence ranged from 98.9% to 96.1% in the 31-210th day after diagnosis, in the follow-up of 291 employees whose total antibody positivity was detected after diagnosis. According to the results of the Joinpoint regression analysis, after the diagnosis of COVID-19, the curve showing the percentage of antibody positivity was broken at two points: The first breaking point was observed in 181-210th days (6-7 months) (p= 0.069), and the second breaking point was in 271-300th days (9-10 months) (p< 0.001). As a result, the highest antibody positivity rates were detected after the 30th day of the disease onset and antibody positivity was maintained in the first seven months after diagnosis; the antibody positivity rate decreased to 25% at the end of the first year.

• Authors: Erhan Eser, Şebnem Şenol Akar, Sinem Akçalı, Talat Ecemiş, Pınar Erbay Dündar, Kübra Çiçek, Damla Akman, Ecem Tüzün, Gülsüm Şanlı Erkekoğlu, Zeynep Ceyda Buran, Zeynep Öykü Öztürk Arıkan, Ferya Karadağ Yalçın
• Journal: Mikrobiyoloji bulteni (Mikrobiyol Bul) Vol. 56 Issue 2 Pg. 274-287 (Apr 2022) ISSN: 0374-9096 [Print] Turkey
• Vernacular Title: Sağlık Çalışanları SARS-CoV-2 Hasta Kohordunda Antikor Sürdürülebilirliği.
• PMID: 35477230 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral

Topics

• Antibodies, Viral
• COVID-19 (diagnosis)
• Delivery of Health Care
• Female
• Humans
• Male
• SARS-CoV-2