Effect of advanced glycation end products on nocturia or sleep disorders: A longitudinal study.

Abstract

Objective:

This study aimed to investigate the effect of advanced glycation end products (AGEs) on nocturia and sleep disorders in community-dwelling adults.

Materials and Methods:

This longitudinal study evaluated AGEs level, sleep disorders and nocturia frequency in 447 community-dwelling adults between May 2011 and May 2016. Sleep disorders were evaluated using the Pittsburgh Sleep Quality Index (PSQI) score. Participants were divided into two groups: AGEs-low (≤1.80) and AGEs-high (>1.80). The longitudinal nocturia and PSQI changes for 5 years between the AGEs-low and AGEs-high groups were compared. The effect of baseline oxidative stress on worsening of nocturia or PSQI score 5 years later was evaluated using multivariable logistic regression analyses.

Results:

There was no significant difference in PSQI score and nocturia frequency between the AGEs-low (n = 223) and AGEs-high (n = 224) groups at baseline. The PSQI score and nocturia frequency increased significantly over 5 years in both groups. However, the PSQI score increased significantly in the AGEs-high group compared with the AGEs-low group, although there was no difference in nocturia. Background-adjusted multivariable analysis showed that the AGE-high was significantly associated with PSQI score worsening, but AGE-high was not significantly associated with nocturia worsening.

Conclusions:

Oxidative stress may be significantly associated with worsening sleep disorders, although oxidative stress may not significantly worsen nocturia frequency.

• Authors: Sakae Konishi, Shingo Hatakeyama, Atsushi Imai, Kazutaka Okita, Koichi Kido, Yusuke Ozaki, Nozomi Uemura, Takuro Iwane, Teppei Okamoto, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama
• Journal: BJUI compass (BJUI Compass) Vol. 3 Issue 2 Pg. 162-168 (Mar 2022) ISSN: 2688-4526 [Electronic] United States
• PMID: 35474730 (Publication Type: Journal Article)
• Copyright: © 2021 The Authors. BJUI Compass published by John Wiley & Sons Ltd on behalf of BJU International Company.