[1st clinical therapeutic trial of mebendazole in some cases of helmenthiasis in Cuba].

Abstract

Due to the difficulties faced in the etiologic approach of trichuriasis as a result of the intolerance, reduced efficacy and toxicity of some drugs a clinical-therapeutic trial of mebendazole was started in 5-64 year-old patients with some form of helmynthiasis as trichuriasis, enterobiasis or necatoriasis. Coproparasitological examinations carried out 15, 30 and 45 days after the ingestion of the drug depicted an excellent cure rate (98% in trichuriasis; 100% in enterobiasis; and 85% in necatoriasis). Very few side-effects were found. This is the first clinical-therapeutic trial of mebendazole in parasitic diseases in our country, and it can be affirmed that results have been very positive and also that they are similar to those obtained by foreign authors.

• Authors: R Otero Domínguez, M Galvez Oviedo, B Estevez Cazallas
• Journal: Revista cubana de medicina tropical (Rev Cubana Med Trop) 1977 Jan-Apr Vol. 29 Issue 1 Pg. 13-6 ISSN: 0375-0760 [Print] Cuba
• Vernacular Title: Primer ensayo clínico-terapéutico en Cuba con mebendazole en algunas helmintiasis.
• PMID: 354640 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Benzimidazoles
• Mebendazole

Topics

• Adolescent
• Adult
• Aged
• Benzimidazoles (therapeutic use)
• Child
• Child, Preschool
• Clinical Trials as Topic
• Drug Evaluation
• Female
• Helminthiasis (drug therapy)
• Humans
• Male
• Mebendazole (therapeutic use)
• Middle Aged