HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Migraine and drug absorption.

Abstract
The majority of migraine attacks are associated with gastrointestinal symptoms which add considerably to the distress and inconvenience caused by the headache. When salicylate absorption from effervescent aspirin tablets was studied during migraine, the rate of absorption was found to be reduced relative to that found in non-migrainous volunteers and in the same patients when headache-free. There is evidence that this reduced rate of absorption is caused by gastrointestinal stasis and reduced rate of gastric emptying. Patients in whom aspirin absorption was delayed were more likely to take longer to respond and to require additional treatment. Metoclopramide, which increases gastric emptying rate, has been shown to improve the rate of absorption of aspirin during migraine and also increase the rate of recovery from the attack and avoid the need for additional treatment; effects which were not shown by thiethylperazine. It is likely that delayed absorption during migraine affects some drugs other than aspirin, such as ergotamine, and it is therefore recommended that the most rapidly absorbable formulation should be used. If such treatment is ineffective, metoclopramide may be a useful addition and should be tried before resorting to other routes of administration.
AuthorsG N Volans
JournalClinical pharmacokinetics (Clin Pharmacokinet) 1978 Jul-Aug Vol. 3 Issue 4 Pg. 313-8 ISSN: 0312-5963 [Print] Switzerland
PMID354637 (Publication Type: Journal Article, Review)
Chemical References
  • Pharmaceutical Preparations
  • Salicylates
  • Ergotamine
  • Aspirin
Topics
  • Aspirin (metabolism)
  • Ergotamine (metabolism)
  • Humans
  • Intestinal Absorption
  • Migraine Disorders (metabolism)
  • Pharmaceutical Preparations (metabolism)
  • Salicylates (metabolism)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: