Abstract |
Outer membrane proteins (OMP) extracted from both smooth (C5) and rough (Rb2) strains of Salmonella typhimurium were able to induce protective immunity to salmonellosis. The OMP-induced protection lasted for at least 6 months. The antibody level was estimated by passive hemagglutination. In the C5 OMP-immunized mice, antibodies to both proteins and lipopolysaccharide were detected. On the other hand, in the Rb2 OMP-immunized mice, antiprotein but not antilipopolysaccharide antibodies were detected. Delayed-type hypersensitivity appeared as early as the second week after immunization with OMP and persisted through the fourth week.
|
Authors | V Udhayakumar, V R Muthukkaruppan |
Journal | Infection and immunity
(Infect Immun)
Vol. 55
Issue 3
Pg. 816-21
(Mar 1987)
ISSN: 0019-9567 [Print] United States |
PMID | 3546142
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibodies, Bacterial
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Lipopolysaccharides
|
Topics |
- Animals
- Antibodies, Bacterial
(biosynthesis)
- Bacterial Outer Membrane Proteins
(immunology, isolation & purification)
- Bacterial Vaccines
(immunology, isolation & purification)
- Immunity, Cellular
- Immunization
- Lipopolysaccharides
(immunology)
- Mice
- Mice, Inbred BALB C
- Salmonella Infections, Animal
(microbiology, prevention & control)
- Salmonella typhimurium
(analysis, immunology, isolation & purification)
|