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Effect of an interferon inducer, 9-methylstreptimidone, on Candida albicans infection in mice.

Abstract
The protective effect of an interferon inducer with a low molecular weight, 9-methylstreptimidone (9-MS), against Candida albicans infection in mice was investigated. The antibiotic was effective only when given prophylactically. When administered in such a manner, the growth of C. albicans in the kidneys and brain was inhibited at the initial stage of infection. The growth of C. albicans was not inhibited by the antibiotic in vitro, and no antifungal effect was obtained in a preparation containing induced interferon. These results suggest that the antifungal action of 9-methylstreptimidone in mice might be manifested not by direct antifungal activity but rather by a host-mediated activity that excludes interferon-inducing capability.
AuthorsT Umenai, F Suzuki, N Ishida
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 13 Issue 6 Pg. 939-43 (Jun 1978) ISSN: 0066-4804 [Print] United States
PMID354522 (Publication Type: Journal Article)
Chemical References
  • Interferon Inducers
  • Piperidines
  • Piperidones
  • Interferons
Topics
  • Animals
  • Candida albicans (drug effects, growth & development)
  • Candidiasis (drug therapy)
  • Female
  • Interferon Inducers (therapeutic use)
  • Interferons (therapeutic use)
  • Mice
  • Piperidines (therapeutic use)
  • Piperidones (therapeutic use)
  • Time Factors

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