A Preliminary Study on the Relationship between Serum Heparan Sulfate and Cancer-Related Cognitive Impairment: The Moderating Role of Oxidative Stress in Patients with Colorectal Cancer.

Abstract	Cancer-related cognitive impairment (CRCI) has been frequently reported in colorectal cancer survivors. Heparan sulfate (HS) was gradually considered to be related to cognitive disorders. The effect and potential mechanism of HS on CRCI in colorectal cancer patients were unexplored. In this study, all participants were divided into a cognitive impaired group and a cognitive normal group. The concentrations of oxidative stress factors and HS in serum were detected. Associations among HS, oxidative stress factors and CRCI were evaluated. Participants with cognitive impairment exhibited increased levels of HS, GSH, SOD and MDA, compared to the patients with normal cognitive performance. The independent significant association was found between HS and CRCI after controlling for various covariates. The higher concentrations of HS were related to the decreased cognitive performance among survivors who reported higher levels of GSH (β = 0.080, p = 0.002). Moreover, the nonlinear association between the level of HS and cognitive scores was confirmed using the restricted cubic splines (p < 0.001). These results indicated that the increased concentrations of circulating HS had a nonlinear negative connection with cognitive performance in colorectal cancer survivors, which was moderated by GSH. HS might be a new biomolecule for the identification and management of patients with CRCI.
Authors	Danhui Wang, Teng Wang, Min Zhu, Jun Sun, Zhou Zhou, Jinghua Chen, Liping Teng
Journal	Current oncology (Toronto, Ont.) (Curr Oncol) Vol. 29 Issue 4 Pg. 2681-2694 (04 12 2022) ISSN: 1718-7729 [Electronic] Switzerland
PMID	35448193 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Heparitin Sulfate
Topics	Cancer Survivors (psychology) Cognitive Dysfunction (etiology, psychology) Colorectal Neoplasms (complications) Heparitin Sulfate Humans Oxidative Stress

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